Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties.

ABSTRACT: 3D porous scaffolds based on agarose and nanocrystalline apatite, two structural components that act as a temporary mineralized extracellular matrix, were prepared by the GELPOR3D method. This shaping technology allows the introduction of thermally-labile molecules within the scaffolds during the fabrication procedure. An angiogenic protein, Vascular Endothelial Growth Factor, and an antibiotic, cephalexin, loaded in mesoporous silica nanoparticles, were included to design multifunctional scaffolds for bone reconstruction. The dual release of both molecules showed a marked increase in the number of blood vessels on embryonic day 14 in chicken embryos grown ex ovo, while, at the same time providing an antibiotic local concentration capable of inhibiting Staphylococcus aureus bacterial growt

SUBMITTER: Paris JL 

PROVIDER: S-EPMC6667335 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature