Cyanobacterial extract with serotonin receptor subtype 7 (5-HT₇ R) affinity modulates depression and anxiety-like behavior in mice.

ABSTRACT: Marine cyanobacteria represent a unique source in the field of drug discovery due to the secondary metabolites they produce and the structural similarity these compounds have to endogenous mammalian receptor ligands. A series of cyanobacteria were subjected to extraction, fractionation by column chromatography and screened for affinity against CNS targets with a focus on serotonin receptors (5-HTRs). Out of 276 fractions screened, 21% had activity at 5-HTRs and/or the 5-HT transporter (SERT). One sample, a cyanobacterium identified by 16S rRNA sequencing as Leptolyngbya from Las Perlas archipelago in Panama, contained a fraction with noted affinity for the 5-HT₇ receptor (5-HT₇ R). This fraction (DUQ0002I) was screened via intracerebroventricular (ICV) injections in m

SUBMITTER: Lax NC 

PROVIDER: S-EPMC6667355 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature