Prospective evaluation of the performance of [⁶⁸Ga]Ga-PSMA-11 PET/CT(MRI) for lymph node staging in patients undergoing superextended salvage lymph node dissection after radical prostatectomy.

ABSTRACT:

Purpose

To assess the accuracy of [⁶⁸Ga]-PSMA-11 PET/CT or [⁶⁸Ga]-PSMA-11 PET/MRI (PSMA-11 PET/CT(MRI)) for lymph node (LN) staging using salvage LN dissection (SLND) in patients with biochemical recurrence (BCR) after radical prostatectomy (RP).

Patients and methods

In a prospective study, 65 consecutive patients who developed BCR after RP underwent SLND after PSMA-11 PET/CT(MRI) between 2014 and 2018. Extended SLND up to the inferior mesenteric artery was performed in all patients. Regional and template-based correlations between the presence of LN metastases on histopathology and whole-body PSMA-11 PET/CT(MRI) results were evaluated. The diagnostic accuracy of PSMA-11 PET/CT(MRI) was also evaluated in relation to PSA level at the time of SLND.

Res

SUBMITTER: Abufaraj M 

PROVIDER: S-EPMC6667405 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature