Reelin is modulated by diet-induced obesity and has direct actions on arcuate proopiomelanocortin neurons.

ABSTRACT:

Objective

Reelin (RELN) is a large glycoprotein involved in synapse maturation and neuronal organization throughout development. Deficits in RELN signaling contribute to multiple psychological disorders, such as autism spectrum disorder, schizophrenia, and bipolar disorder. Nutritional stress alters RELN expression in brain regions associated with these disorders; however, the involvement of RELN in the neural circuits involved in energy metabolism is unknown. The RELN receptors apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor (VLDLR) are involved in lipid metabolism and expressed in the hypothalamus. Here we explored the involvement of RELN in hypothalamic signaling and the impact of diet-induced obesity (DIO) on this system.

Methods

Adult male

SUBMITTER: Roberts BL 

PROVIDER: S-EPMC6667498 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature