Ontology highlight
ABSTRACT:
SUBMITTER: Ke H
PROVIDER: S-EPMC6667501 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Ke Hanzhong H Lee Sera S Kim Jineui J Liu Hsiao-Ching HC Yoo Dongwan D
Scientific reports 20190730 1
Porcine reproductive and respiratory syndrome virus (PRRSV) activates NF-κB during infection. We examined the ability of all 22 PRRSV genes for NF-κB regulation and determined the nucleocapsid (N) protein as the NF-κB activator. Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) (PIAS1) was identified as a cellular protein binding to N. PIAS1 is known to bind to p65 (RelA) in the nucleus and blocks its DNA binding, thus functions as a repressor of NF-κB. Bi ...[more]