The lytic transglycosylase, LtgG, controls cell morphology and virulence in Burkholderia pseudomallei.

ABSTRACT: Burkholderia pseudomallei is the causative agent of the tropical disease melioidosis. Its genome encodes an arsenal of virulence factors that allow it, when required, to switch from a soil dwelling bacterium to a deadly intracellular pathogen. With a high intrinsic resistance to antibiotics and the ability to overcome challenges from the host immune system, there is an increasing requirement for new antibiotics and a greater understanding into the molecular mechanisms of B. pseudomallei virulence and dormancy. The peptidoglycan remodeling enzymes, lytic transglycosylases (Ltgs) are potential targets for such new antibiotics. Ltgs cleave the glycosidic bonds within bacterial peptidoglycan allowing for the insertion of peptidoglycan precursors during cell growth and division, and cell membra

SUBMITTER: Jenkins CH 

PROVIDER: S-EPMC6667503 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature