Postponement of Death by Statin Use: a Systematic Review and Meta-analysis of Randomized Clinical Trials.

ABSTRACT:

Background

The average postponement of the outcome (gain in time to event) has been proposed as a measure to convey the effect of preventive medications. Among its advantages over number needed to treat and relative risk reduction is a better intuitive understanding among lay persons.

Objectives

To develop a novel approach for modeling outcome postponement achieved within a trial's duration, based on published trial data and to present a formalized meta-analysis of modeled outcome postponement for all-cause mortality in statin trials.

Methods

The outcome postponement was modeled on the basis of the hazard ratio or relative risk, the mortality rate in the placebo group and the trial's duration. Outcome postponement was subjected to a meta-analysis. We also estimated th

SUBMITTER: Hansen MR 

PROVIDER: S-EPMC6667545 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature