Sensitivity of ¹⁸F-fluorodihydrotestosterone PET-CT to count statistics and reconstruction protocol in metastatic castration-resistant prostate cancer.

ABSTRACT:

Objectives

Whole body [¹⁸F]-fluorodihydrotestosterone positron emission tomography ([¹⁸F]FDHT PET) imaging directly targets the androgen receptor and is a promising prognostic and predictive biomarker in metastatic castration-resistant cancer (mCRPC). To optimize [¹⁸F]FDHT PET-CT for diagnostic and response assessment purposes, we assessed how count statistics and reconstruction protocol affect its accuracy, repeatability, and lesion detectability.

Methods

Whole body [¹⁸F]FDHT PET-CT scans were acquired on an analogue PET-CT on two consecutive days in 14 mCRPC patients harbouring a total of 336 FDHT-avid lesions. Images were acquired at 45 min post-injection of 200 MBq [¹⁸F]FDHT at 3 min per bed position. List-mode PET d

SUBMITTER: Cysouw MCF 

PROVIDER: S-EPMC6667590 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature