Improved antioxidant, antimicrobial and anticancer activity of naringenin on conjugation with pectin.

ABSTRACT: The purpose of the present study was to improve the aqueous solubility of naringenin by conjugating with water-soluble polysaccharide carrier, pectin. The pectin-naringenin conjugate was synthesized employing dicyclohexylcarbodiimide and dimethylaminopyridine. The conjugation was confirmed by various physicochemical characterizations. The results of differential scanning calorimetry, X-ray diffraction and morphological analyses revealed semi-crystalline nature of the conjugate. The chromatographic analysis showed 37.069 µg naringenin/mg of conjugate. The conjugate was determined to have molecular weight of 6.22 × 10⁴ kDa by static light scattering. In silico molecular mechanistic simulations performed for pectin and naringenin revealed the energetic and geometrical stability wit

SUBMITTER: Mundlia J 

PROVIDER: S-EPMC6667600 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature