Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review.

ABSTRACT: We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case-control study; in three other case-control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case-control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis t

SUBMITTER: Lukasik J 

PROVIDER: S-EPMC6667689 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature