Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition.

ABSTRACT:

Background

Development of a cytomegalovirus (CMV) vaccine is a high priority. However, the ability of antibodies to protect against CMV infection is not well characterized. Studies of maternal antibodies in infants offer the potential to identify humoral correlates of protection against postnatal acquisition.

Methods

This hypothesis-generating study analyzed 29 Ugandan mother-infant pairs that were followed weekly for CMV acquisition. Seventeen mothers and no infants were infected with human immunodeficiency virus (HIV). We evaluated the association between CMV-specific immunoglobulin G (IgG) responses in mothers at the time of delivery and their infants' CMV status at 6 months of age. We also assessed levels of CMV-specific IgG in infants at 6 weeks of age. CMV-specific IgG

SUBMITTER: Saccoccio FM 

PROVIDER: S-EPMC6667799 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature