Gene expression and DNA methylation regulation of arsenic in mouse bladder tissues and in human urothelial cells.

ABSTRACT: According to a report of the International Agency for Research on Cancer, arsenic and inorganic arsenic compounds are classified into Group 1 carcinogens with regard to human health. Epidemiological studies indicate that arsenic is one of the main risk factors for the development of bladder cancer. In the present study, arsenic‑altered gene expression in mouse bladder tissues and in human urothelial cells was compared. In the mouse model, sodium arsenite‑induced mouse urothelial hyperplasia and intracellular inclusions were present. Following DNA array analysis, four genes with differential expression were selected for quantitative real‑time PCR assay. The genes were the following: Cystathionine β‑synthase (CBS), adenosine A1 receptor (ADORA1), metastasis‑associated lung adenocarcinoma tra

SUBMITTER: Jou YC 

PROVIDER: S-EPMC6667867 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature