Identification and characterization of sexual dimorphism‑linked gene expression profile in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is sexually disparate in humans, with a significantly increased prevalence in males. The molecular mechanisms by which the inhibition or development of liver cancer are facilitated require further investigation with regard to sex factors affecting disease progression. In the present study, functional signatures of differentially expressed genes (DEGs) were screened in female and male tumors via bioinformatics analysis. The following gene chip expression profiles were downloaded from the Gene Expression Omnibus: GSE19665, GSE23342 and GSE9843. They comprised cancerous and non‑cancerous tissue from patients with HCC and included critical sex features. Further evaluation of selected DEGs in the two sexual groups was performed via hierarchical clustering analysis

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6667920 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature