Principles of Effective and Robust Innate Immune Response to Viral Infections: A Multiplex Network Analysis.

ABSTRACT: The human innate immune response, particularly the type-I interferon (IFN) response, is highly robust and effective first line of defense against virus invasion. IFN molecules are produced and secreted from infected cells upon virus infection and recognition. They then act as signaling/communication molecules to activate an antiviral response in neighboring cells so that those cells become refractory to infection. Previous experimental studies have identified the detailed molecular mechanisms for the IFN signaling and response. However, the principles underlying how host cells use IFN to communicate with each other to collectively and robustly halt an infection is not understood. Here we take a multiplex network modeling approach to provide a theoretical framework to identify key factors t

SUBMITTER: Huang Y 

PROVIDER: S-EPMC6667926 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature