The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro.

ABSTRACT:

Purpose

Since the 2014 Ebola virus (EBOV) outbreak in West Africa there has been considerable effort towards developing drugs to treat Ebola virus disease and yet to date there is no FDA approved treatment. This is important as at the time of writing this manuscript there is an ongoing outbreak in the Democratic Republic of the Congo which has killed over 1000.

Methods

We have evaluated a small number of natural products, some of which had shown antiviral activity against other pathogens. This is exemplified with eugenol, which is found in high concentrations in multiple essential oils, and has shown antiviral activity against feline calicivirus, tomato yellow leaf curl virus, Influenza A virus, Herpes Simplex virus type 1 and 2, and four airborne phages.

Results

Four

SUBMITTER: Lane T 

PROVIDER: S-EPMC6668022 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature