Local ice cryotherapy decreases synovial interleukin 6, interleukin 1β, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study.

ABSTRACT:

Background

The aim of this study was to assess the anti-inflammatory effects of local cryotherapy in human non-septic knee arthritis.

Methods

In the phase I of the study, patients were randomized to receive either ice (30 min; N = 16) or cold CO₂ (2 min; N = 16) applied twice during 1 day at an 8-h interval on the arthritic knee. In phase II, 16 other ice-treated arthritic knees according to the same protocol were compared to the contralateral non-treated arthritic knees (N = 16). The synovial fluid was analyzed just before the first cold application, then 24 h later. IL-6, IL-1β, TNF-α, IL-17A, VEGF, NF-kB-p65 protein, and PG-E2 levels were measured in the synovial fluid and compared before/after the two cold applications.

Results

Forty-seven patients were

SUBMITTER: Guillot X 

PROVIDER: S-EPMC6668066 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature