Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.

ABSTRACT:

Background

No study has been conducted to demonstrate the feasibility of an opioid-free anesthesia (OFA) protocol in cardiac surgery to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative morphine consumption and the post-operative course.

Methods

After retrospectively registering to clinicaltrial.gov (NCT03816592), we performed a retrospective matched cohort study (1:1) on cardiac surgery patients with cardiopulmonary bypass between 2018 and 2019. Patients were divided into two groups: OFA (lidocaine, dexamethasone and ketamine) or opioid anaesthesia (OA) (sufentanil). The main outcome was the total postoperative morphine consumption in the 48 h after surgery. Secondary outcomes were rescue analgesic use, a major adverse ev

SUBMITTER: Guinot PG 

PROVIDER: S-EPMC6668113 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature