Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice.

ABSTRACT:

Background

The regenerative ability of severed axons in the central nervous system is limited in mammals. However, after central nervous system injury, neural function is partially recovered by the formation of a compensatory neural circuit. In a mouse pyramidotomy model, axonal sprouting of the intact side of the corticospinal tract is observed in the spinal cord, and the axons make new synapses with the denervated side of propriospinal neurons. Moreover, this sprouting ability is enhanced in neonatal mice compared to that in adult mice. Myelin-associated molecules in the spinal cord or intrinsic factors in corticospinal neurons have been investigated in previous studies, but the factors that determine elevated sprouting ability in neonatal mice are not fully understood. Further,

SUBMITTER: Tsujioka H 

PROVIDER: S-EPMC6668129 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature