Molecular characterization and functional analysis of the Schistosoma mekongi Ca²⁺-dependent cysteine protease (calpain).

ABSTRACT:

Background

Schistosoma mekongi, which causes schistosomiasis in humans, is an important public health issue in Southeast Asia. Treatment with praziquantel is the primary method of control but emergence of praziquantel resistance requires the development of alternative drugs and vaccines. Calcium-dependent cysteine protease (calpain) is a novel vaccine candidate that has been studied in S. mansoni, S. japonicum, and protozoans including malaria, leishmania and trypanosomes. However, limited information is available on the properties and functions of calpain in other Schistosoma spp., including S. mekongi. In this study, we functionally characterized calpain 1 of S. mekongi (SmeCalp1).

Results

Calpain 1 of S. mekongi was obtained from transcriptomic analysis of S. mekongi; it

SUBMITTER: Chaimon S 

PROVIDER: S-EPMC6668146 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature