Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy.

ABSTRACT:

Background

Little is known about tumor-associated vasogenic edema in brain metastasis, yet it causes significant morbidity and mortality. Our purpose was to characterize edema in patients treated with anti-PD-1 and to study potential causes of vessel leakage in humans and in pre-clinical models.

Methods

We analyzed tumor and edema volume in 18 non-small cell lung (NSCLC) and 18 melanoma patients with untreated brain metastases treated with pembrolizumab on a phase II clinical trial. Melanoma brain metastases were stained with anti-CD34 to assess vessel density and its association with edema. We employed an in vitro model of the blood-brain barrier using short-term cultures from melanoma brain and extracranial metastases to determine tight junction resistance as a measure of

SUBMITTER: Tran TT 

PROVIDER: S-EPMC6668163 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature