Bluetongue virus outer-capsid protein VP2 expressed in <i>Nicotiana benthamiana</i> raises neutralising antibodies and a protective immune response in IFNAR ^-/- mice.

ABSTRACT: Bluetongue is a severe, economically important disease of ruminants that is widely distributed in tropical and temperate regions around the world. It is associated with major production losses, restrictions of animal movements and trade, as well as costs associated with developing and implementing effective surveillance and control measures. Mammalian hosts infected with bluetongue virus (BTV) generate a protective neutralising antibody response targeting the major BTV outer-capsid protein and serotype-specific antigen, VP2. BTV VP2 proteins that have been expressed in plants are soluble, with a native conformation displaying neutralising epitopes and can assemble with other BTV structural proteins to form virus-like particles (VLPs). His-tagged VP2 proteins of BTV serotypes 4 and 8 were t

SUBMITTER: Fay PC 

PROVIDER: S-EPMC6668234 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature