Genotyping low-grade gliomas among Hispanics.

ABSTRACT:

Background

Low-grade gliomas (LGGs) are classified by the World Health Organization as astrocytoma (DA), oligodendroglioma (OD), and mixed oligoastrocytoma (OA). TP53 mutation and 1p19q codeletion are the most-commonly documented molecular abnormalities. Isocitrate dehydrogenase (IDH) 1/2 mutations are frequent in LGGs; however, IDH-negative gliomas can also occur. Recent research suggests that ATRX plays a significant role in gliomagenesis.

Methods

We investigated p53 and Olig2 protein expression, and MGMT promoter methylation, 1p19q codeletion, IDH, and ATRX status in 63 Colombian patients with LGG. The overall survival (OS) rate was estimated and compared according to genotype.

Results

The most common histology was DA, followed by OD and OA. IDH1/2 mu

SUBMITTER: Cardona AF 

PROVIDER: S-EPMC6668282 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature