LEI: A Novel Allele Frequency-Based Feature Selection Method for Multi-ancestry Admixed Populations.

ABSTRACT: Next-generation sequencing technologies now make it possible to sequence and genotype hundreds of thousands of genetic markers across the human genome. Selection of informative markers for the comprehensive characterization of individual genomic makeup using a high dimensional genomics dataset has become a common practice in evolutionary biology and human genetics. Although several feature selection approaches exist to determine the ancestry proportion in two-way admixed populations including African Americans, there are limited statistical tools developed for the feature selection approaches in three-way admixed populations (including Latino populations). Herein, we present a new likelihood-based feature selection method called Lancaster Estimator of Independence (LEI) that utilizes allel

SUBMITTER: Wathen MJ 

PROVIDER: S-EPMC6668412 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature