Mapping brain function during naturalistic viewing using high-density diffuse optical tomography.

ABSTRACT: Naturalistic stimuli, such as movies, more closely recapitulate "real life" sensory processing and behavioral demands relative to paradigms that rely on highly distilled and repetitive stimulus presentations. The rich complexity inherent in naturalistic stimuli demands an imaging system capable of measuring spatially distributed brain responses, and analysis tools optimized for unmixing responses to concurrently presented features. In this work, the combination of passive movie viewing with high-density diffuse optical tomography (HD-DOT) is developed as a platform for naturalistic brain mapping. We imaged healthy young adults during free viewing of a feature film using HD-DOT and observed reproducible, synchronized cortical responses across a majority of the field-of-view, most prominentl

SUBMITTER: Fishell AK 

PROVIDER: S-EPMC6668456 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature