Analysis of Protein-Protein Functional Associations by Using Gene Ontology and KEGG Pathway.

ABSTRACT: Protein-protein interaction (PPI) plays an extremely remarkable role in the growth, reproduction, and metabolism of all lives. A thorough investigation of PPI can uncover the mechanism of how proteins express their functions. In this study, we used gene ontology (GO) terms and biological pathways to study an extended version of PPI (protein-protein functional associations) and subsequently identify some essential GO terms and pathways that can indicate the difference between two proteins with and without functional associations. The protein-protein functional associations validated by experiments were retrieved from STRING, a well-known database on collected associations between proteins from multiple sources, and they were termed as positive samples. The negative samples were constructed

SUBMITTER: Yuan F 

PROVIDER: S-EPMC6668538 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature