Site-Specific DC Surface Signatures Influence CD4⁺ T Cell Co-stimulation and Lung-Homing.

ABSTRACT: Dendritic cells (DCs) that drain the gut and skin are known to favor the establishment of T cell populations that home to the original site of DC-antigen (Ag) encounter by providing soluble "imprinting" signals to T cells in the lymph node (LN). To study the induction of lung T cell-trafficking, we used a protein-adjuvant murine intranasal and intramuscular immunization model to compare in vivo-activated Ag⁺ DCs in the lung and muscle-draining LNs. Higher frequencies of Ag⁺ CD11b⁺ DCs were observed in lung-draining mediastinal LNs (MedLN) compared to muscle-draining inguinal LNs (ILN). Ag⁺ CD11b⁺ MedLN DCs were qualitatively superior at priming CD4⁺ T cells, which then expressed CD49a and CXCR3, and preferentia

SUBMITTER: Pejoski D 

PROVIDER: S-EPMC6668556 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature