A Novel Animal Model for Regional Microbial Dysbiosis of the Pioneer Microbial Community.

ABSTRACT: Pioneer microbiota colonizing the newborn gastrointestinal tract has long-lasting effects on host health. Restoration of the gut microbial community, following dysbiosis during the neonatal period, may be one strategy to prevent undesirable health outcomes linked to an altered neonatal gut microbiome. Without appropriate animal models that recreate the prolonged human neonatal developmental period it is not possible to effectively analyze interventions designed to restore regional microbial populations. Our study used a lamb model in which intestinal segments were surgically isolated (blind-ended) in fetal lambs to create early microbial dysbiosis by delaying post-natal exposure to intestinal ingesta. Intestinal segments isolated in utero retained blood flow, innervation, and lympha

SUBMITTER: Malmuthuge N 

PROVIDER: S-EPMC6668574 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature