Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.

ABSTRACT: Facial allodynia is a migraine symptom that is generally considered to represent a pivotal point in migraine progression. Treatment before development of facial allodynia tends to be more successful than treatment afterwards. As such, understanding the underlying mechanisms of facial allodynia may lead to a better understanding of the mechanisms underlying migraine. Migraine facial allodynia is modeled by applying inflammatory soup (histamine, bradykinin, serotonin, prostaglandin E2) over the dura. Whether glial and/or immune activation contributes to such pain is unknown. Here we tested if trigeminal nucleus caudalis (Sp5C) glial and/or immune cells are activated following supradural inflammatory soup, and if putative glial/immune inhibitors suppress the consequent facial allodynia. Infla

SUBMITTER: Wieseler J 

PROVIDER: S-EPMC6668623 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature