Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.

ABSTRACT:

Background

Cervicitis is one of the major health problems amongst women caused by infection of various pathogens including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) as well as human papillomavirus (HPV), and persistent cervical inflammation is one of the etiologic agents of cervical cancer. Toll-like receptors (TLRs) play an important role in the recognition and subsequent elimination of these pathogens. Variations in the Toll-like receptor genes influence susceptibility to pathogens as well as disease progression independently.

Methods

Ten single nucleotide polymorphisms, five each of TLR4 and TLR9 genes were analyzed among 130 cervicitis patients and 150 controls either using polymerase chain reaction-restriction fragment length pol

SUBMITTER: Chauhan A 

PROVIDER: S-EPMC6668796 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature