LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation.

ABSTRACT: The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo suppresses nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling in pancreatic progenitors to permit cell differentiation and epithelial morphogenesis. We find that pancreas-specific deletion of the large tumor suppressor kinases 1 and 2 (Lats1/2PanKO) from mouse progenitor epithelia results in failure to differentiate key pancreatic lineages: acinar, ductal, and endocrine. We carried out an unbiased transcriptome analysis to query differentiation defect

SUBMITTER: Braitsch CM 

PROVIDER: S-EPMC6668837 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature