Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates.

ABSTRACT: A growing body of evidence supports the notion that variation in gene regulation plays a crucial role in both speciation and adaptation. However, a comprehensive functional understanding of the mechanisms underlying regulatory evolution remains elusive. In primates, one of the crucial missing pieces of information towards a better understanding of regulatory evolution is a comparative annotation of interactions between distal regulatory elements and promoters. Chromatin conformation capture technologies have enabled genome-wide quantifications of such distal 3D interactions. However, relatively little comparative research in primates has been done using such technologies. To address this gap, we used Hi-C to characterize 3D chromatin interactions in induced pluripotent stem cells (iPSCs) f

SUBMITTER: Eres IE 

PROVIDER: S-EPMC6668850 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature