Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.

ABSTRACT: Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and othe

SUBMITTER: Lind AL 

PROVIDER: S-EPMC6668926 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature