Clinical outcomes in pediatric intestinal failure: a meta-analysis and meta-regression.

ABSTRACT:

Background

Intestinal failure (IF) is associated with significant morbidity and mortality, yet specific parameters that determine medium- and long-term outcomes remain ill defined.

Objective

The aim of this study was to determine the long-term outcomes in childhood IF and identify patient characteristics associated with clinical endpoints.

Design

MEDLINE and EMBASE were searched for cohorts of >10 pediatric-onset IF patients with >12 mo follow-up. Random-effects meta-analysis and meta-regression weighted by follow-up duration were used to calculate clinical outcome rates and patient factors associated with outcomes. Primary outcome was mortality rate; secondary outcomes included neurodevelopmental status, transplantation, IF-associated liver disease (IFALD), enteral a

SUBMITTER: Pierret ACS 

PROVIDER: S-EPMC6669059 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature