Genome-wide association study of breakfast skipping links clock regulation with food timing.

ABSTRACT:

Background

Little is known about the contribution of genetic variation to food timing, and breakfast has been determined to exhibit the most heritable meal timing. As breakfast timing and skipping are not routinely measured in large cohort studies, alternative approaches include analyses of correlated traits.

Objectives

The aim of this study was to elucidate breakfast skipping genetic variants through a proxy-phenotype genome-wide association study (GWAS) for breakfast cereal skipping, a commonly assessed correlated trait.

Methods

We leveraged the statistical power of the UK Biobank (n = 193,860) to identify genetic variants related to breakfast cereal skipping as a proxy-phenotype for breakfast skipping and applied several in silico approaches to investigate mechanis

SUBMITTER: Dashti HS 

PROVIDER: S-EPMC6669061 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature