Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring.

ABSTRACT:

Importance

Evidence for the fetal safety of ondansetron, a 5-HT3 receptor antagonist that is commonly prescribed for nausea and vomiting during pregnancy, is limited and conflicting.

Objective

To evaluate the association between ondansetron exposure during pregnancy and risk of congenital malformations.

Design, setting, and participants

A retrospective cohort study nested in the 2000-2013 nationwide Medicaid Analytic eXtract. The cohort consisted of 1 816 414 pregnancies contributed by 1 502 895 women enrolled in Medicaid from 3 months before the last menstrual period through 1 month or longer after delivery; infants were enrolled in Medicaid for at least 3 months after birth. The final date of follow-up was December 31, 2013. Analyses were conducted between November

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC6669077 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature