Cochlear pharmacokinetics - Micro-computed tomography and learning-prediction modeling for transport parameter determination.

ABSTRACT: Inner ear disorders such as sensorineural deafness and genetic diseases may one day be treated with local drug delivery to the inner ear. Current pharmacokinetic models have been based on invasive methods to measure drug concentrations, limiting them in spatial resolution, and restricting the research to larger rodents. We developed an intracochlear pharmacokinetic model based on an imaging, learning-prediction (LP) paradigm for learning transport parameters in the murine cochlea. This was achieved using noninvasive micro-computed tomography imaging of the cochlea during in vivo infusion of a contrast agent at the basal end of scala tympani through a cochleostomy. Each scan was registered in 3-D to a cochlear atlas to segment the cochlear regions with high accuracy, enabling concentrations

SUBMITTER: Moudgalya SS 

PROVIDER: S-EPMC6669082 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature