Antibacterial effects of sodium tripolyphosphate against Porphyromonas species associated with periodontitis of companion animals.

ABSTRACT: Porphyromonas species are closely associated with companion animal periodontitis which is one of the most common diseases in dogs and cats and leads to serious systemic diseases if left untreated. In this study, we evaluated the antimicrobial effects and mode of action of sodium tripolyphosphate (polyP3, Na₅P₃O10), a food additive with proven safety, using three pathogenic Porphyromonas species. The minimum inhibitory concentrations (MICs) of polyP3 against Porphyromonas gulae, Porphyromonas cansulci, and Porphyromonas cangingivalis were between 500 and 750 mg/L. PolyP3 significantly decreased viable planktonic cells as well as bacterial biofilm formation, even at sub-MIC concentrations. PolyP3 caused bacterial membrane disruption and this effect was most

SUBMITTER: Lee JH 

PROVIDER: S-EPMC6669212 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature