Human biodistribution and radiation dosimetry of the 5-HT_2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions.

ABSTRACT:

Background

Cimbi-36 can be ¹¹C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT_2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreational drug that can lead to severe adverse effects, in some cases, with fatal outcome. We investigated human biodistribution and radiation dosimetry of the radioligand with two different radiolabeling positions. Seven healthy volunteers underwent dynamic 120-min whole-body PET scans (injection of 581 ± 16 MBq, n = 5 for ¹¹C-Cimbi-36; 593 ± 14 MBq, n = 2 for ¹¹C-Cimbi-36_5). Time-integrated activity coefficients (TIACs) from time-activity curves (TACs) of selected organs were used as input into the OLINDA/EXM software to obt

SUBMITTER: Johansen A 

PROVIDER: S-EPMC6669221 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature