Optimization of parathyroid ¹¹C-choline PET protocol for localization of parathyroid adenomas in patients with primary hyperparathyroidism.

ABSTRACT:

Purpose

To evaluate the optimal tracer uptake time, the minimal amount of radioactivity and the inter-observer agreement for ¹¹C-choline positron emission tomography/computed tomography (PET/CT) in patients with primary hyperparathyroidism (pHPT).

Methods

Twenty-one patients with biochemically proven pHPT were retrospectively studied after injection of 6.3 ± 1.2 MBq/kg ¹¹C-choline. PET data of the first nine patients, scanned for up to 60 min, were reconstructed in 10-min frames from 10- to 60-min postinjection (p.i.), mimicking varying ¹¹C-choline uptake times. Parathyroid adenoma to background contrast ratios were calculated and compared, using standardized uptake values (SUVs). Data was reconstructed with varying scan durations (1, 2.5, 5,

SUBMITTER: Noltes ME 

PROVIDER: S-EPMC6669228 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature