Serum untargeted metabolomic profile of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.

ABSTRACT:

Background

The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjective measures and a few biomarkers from 24-h urine collections.

Objective

The aim of the study was to use metabolomics to identify serum compounds that are associated with adherence to the DASH dietary pattern.

Design

We conducted untargeted metabolomic profiling in serum specimens collected at the end of 8 wk following the DASH diet (n = 110), the fruit and vegetables diet (n = 111), or a control diet (n = 108) in a multicenter, randomized clinical feeding study (n = 329). Multivariable linear regression was used to determine the associations between the randomized diets and indi

SUBMITTER: Rebholz CM 

PROVIDER: S-EPMC6669331 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature