The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank.

ABSTRACT:

Background

Depression and chronic inflammatory medical conditions have been linked to impaired cognitive ability. However despite frequent comorbidity, their combined association with cognitive ability has rarely been examined.

Methods

This study examined associations between self-reported depression and chronic inflammatory diseases and their interaction with cognitive performance in 456,748 participants of the UK Biobank, adjusting for sociodemographic and lifestyle factors. Numbers with available data ranged from 94,899 to 453,208 depending on the cognitive test.

Results

Self-reported depression was associated with poorer performance compared to controls in several cognitive tests (fully adjusted models, reaction time: B = 6.08, 95% CI = 5.09, 7.07; pairs matching:

SUBMITTER: Lyall LM 

PROVIDER: S-EPMC6669333 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature