Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints.

ABSTRACT: The gut microbiome of primates, including humans, is reported to closely follow host evolutionary history, with gut microbiome composition being specific to the genetic background of its primate host. However, the comparative models used to date have mainly included a limited set of closely related primates. To further understand the forces that shape the primate gut microbiome, with reference to human populations, we expanded the comparative analysis of variation among gut microbiome compositions and their primate hosts, including 9 different primate species and 4 human groups characterized by a diverse set of subsistence patterns (n = 448 samples). The results show that the taxonomic composition of the human gut microbiome, at the genus level, exhibits increased compositional plas

SUBMITTER: Gomez A 

PROVIDER: S-EPMC6669335 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature