Signal Sensing and Transduction Are Conserved between the Periplasmic Sensory Domains of BifA and SagS.

ABSTRACT: The hybrid sensor kinase SagS of Pseudomonas aeruginosa plays a key role in the transition from the planktonic to the biofilm mode of growth. Recently, we have shown that distinct sets of residues in its periplasmic HmsP sensory domain are involved in the regulation of biofilm formation or antibiotic tolerance. Interestingly, the HmsP domain of the phosphodiesterase BifA shows great predicted structural similarity to that of SagS, despite moderate sequence conservation and only a number of residues involved in SagS signaling being conserved between both proteins. Based on this observation, we hypothesized that BifA and SagS may use similar mechanisms to sense and transduce signals perceived at their periplasmic HmsP domains and, therefore, may be interchangeable. To test this hypoth

SUBMITTER: Dingemans J 

PROVIDER: S-EPMC6669338 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature