Effects of Arbovirus Multi-Host Life Cycles on Dinucleotide and Codon Usage Patterns.

ABSTRACT: Arthropod-borne viruses (arboviruses) of vertebrates including dengue, zika, chikungunya, Rift Valley fever, and blue tongue viruses cause extensive morbidity and mortality in humans, agricultural animals, and wildlife across the globe. As obligate intercellular pathogens, arboviruses must be well adapted to the cellular and molecular environment of both their arthropod (invertebrate) and vertebrate hosts, which are vastly different due to hundreds of millions of years of separate evolution. Here we discuss the comparative pressures on arbovirus RNA genomes as a result of a dual host life cycle, focusing on pressures that do not alter amino acids. We summarize what is currently known about arboviral genetic composition, such as dinucleotide and codon usage, and how cyclical infection of ve

SUBMITTER: Sexton NR 

PROVIDER: S-EPMC6669465 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature