Complex History of Codiversification and Host Switching of a Newfound Soricid-Borne Orthohantavirus in North America.

ABSTRACT: Orthohantaviruses are tightly linked to the ecology and evolutionary history of their mammalian hosts. We hypothesized that in regions with dramatic climate shifts throughout the Quaternary, orthohantavirus diversity and evolution are shaped by dynamic host responses to environmental change through processes such as host isolation, host switching, and reassortment. Jemez Springs virus (JMSV), an orthohantavirus harbored by the dusky shrew (Sorex monticola) and five close relatives distributed widely in western North America, was used to test this hypothesis. Total RNAs, extracted from liver or lung tissue from 164 shrews collected from western North America during 1983-2007, were analyzed for orthohantavirus RNA by reverse transcription polymerase chain reaction (RT-PCR). Phylogenie

SUBMITTER: Liphardt SW 

PROVIDER: S-EPMC6669566 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature