Costatone C-A New Halogenated Monoterpene from the New Zealand Red Alga Plocamium angustum.

ABSTRACT: Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the planar structure of 7 was achieved through conventional NMR and (-)-HR-APCI-MS techniques, and the absolute configuration by comparison of experimental and DFT-calculated ECD spectra. The absolute configuration of 8 was determined using Mosher's method. Compound 7 showed mild antibacterial activity against Staphylococcus aureus and S. epidermidis. The state of Plocamium taxonomy and its implicatio

SUBMITTER: Bracegirdle J 

PROVIDER: S-EPMC6669586 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature