Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States.

ABSTRACT:

Importance

Retinoids are bioactive forms of vitamin A that are essential in the maintenance of epithelial maturation and differentiation. Synthetic retinoids are used in chemoprevention of skin cancer among high-risk populations with potential adverse effects. Epidemiologic data on vitamin A intake and risk of cutaneous squamous cell carcinoma (SCC) are limited.

Objective

To examine whether vitamin A intake is associated with a reduction in SCC risk.

Design, settings, and participants

This cohort study prospectively examined intake of vitamin A and carotenoids and SCC risk in the Nurses' Health Study (1984-2012) and the Health Professionals Follow-up Study (1986-2012). Diet was assessed repeatedly. Incident SCC was confirmed by pathologic reports. Data analysis was pe

SUBMITTER: Kim J 

PROVIDER: S-EPMC6669777 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature