Effect of Adjunctive Estradiol on Schizophrenia Among Women of Childbearing Age: A Randomized Clinical Trial.

ABSTRACT:

Importance

Several lines of evidence suggest that estradiol influences the course of schizophrenia, and a previous randomized controlled trial demonstrated that transdermal estradiol improved symptoms in female patients of childbearing age. However, many initial positive findings in schizophrenia research are not later replicated.

Objective

To independently replicate the results of the effect of estradiol on schizophrenia in women of childbearing age.

Design, setting, and participants

An 8-week randomized, placebo-controlled trial performed in the Republic of Moldova between December 4, 2015, and July 29, 2016, among 200 premenopausal women aged 19 to 46 years with schizophrenia or schizoaffective disorder as defined by the DSM-5.

Intervention

Patients were ran

SUBMITTER: Weiser M 

PROVIDER: S-EPMC6669788 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature