Association With Hospitalization and All-Cause Discontinuation Among Patients With Schizophrenia on Clozapine vs Other Oral Second-Generation Antipsychotics: A Systematic Review and Meta-analysis of Cohort Studies.

ABSTRACT:

Importance

Recent meta-analyses of randomized clinical trials (RCTs) comparing clozapine with nonclozapine second-generation antipsychotics (NC-SGAs) in schizophrenia have challenged clozapine's superiority in treatment-resistant patients. However, patients in RCTs are not necessarily generalizable to those in clinical practice.

Objective

To conduct a systematic review and meta-analysis to compare various outcomes of clozapine vs oral NC-SGAs in cohort studies.

Data sources

Systematic literature search in PubMed, PsycINFO, and CINAHL without language restriction from database inception until December 17, 2018.

Study selection

Nonrandomized cohort studies reporting effectiveness and/or safety outcomes comparing clozapine with NC-SGAs in schizophrenia or schizoaf

SUBMITTER: Masuda T 

PROVIDER: S-EPMC6669790 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature