Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity.

ABSTRACT:

Context

Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity, or peak oxygen uptake (V̇O2peak), in healthy older men with low testosterone have not been evaluated.

Objective

To determine the effects of testosterone supplementation on V̇O2peak during incremental cycle ergometry.

Design

A double-blind, randomized, placebo-controlled, parallel-group trial (Testosterone's Effects on Atherosclerosis Progression in Aging Men).

Setting

Exercise physiology laboratory.

Participants

Healthy men aged ≥ 60 years with total testosterone levels of 100 to 400 ng/dL (3.5 to 13.9 nmol/L) or free testosterone levels < 50 pg/mL (174 pmol/L).

Interventions

Randomization to 1% transdermal t

SUBMITTER: Traustadottir T 

PROVIDER: S-EPMC6669813 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature